New Preprint is Live!

Our latest study shows that non-productively HIV-infected cells display a distinct immunoregulatory phenotype, and we're excited to share what we found! We discovered that CD4⁺ T memory stem cells harboring non-productive HIV proviruses switch on three immunosuppressive gene programs, involving Treg-recruiting chemokines (CCL22, CCL17), tryptophan-degrading enzymes (IDO1, KYNU), and cytoskeletal remodeling proteins. These findings suggest that non-productive proviruses are associated with a remodeling of the infected cell's immune environment, potentially contributing to HIV reservoir persistence.

Congratulations to first author Dr. Giacomo Butta and all authors!

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