Our Research

Research in the Simon lab focuses on many topics including SARS-CoV-2, seasonal coronaviruses, HIV, latency, restriction factors, viral evolution & diversification, antibodies, endogenous retroviruses and more.

We aim to understand viral-host interactions in the context of human and viral diversity. We are interested in the mode of action of known (APOBEC3 cytidine deaminases, SAMHD1) and novel retroviral restriction factors as well as the corresponding HIV, SIV and HTLV antagonists.

In addition, we study the mechanisms driving viral drug resistance as well as viral diversification, the roles of RNA modifications in viral replication and HIV persistence in CD4+ T memory stem cells. Watch the video to learn more!